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> home > Products > Primary Antibodies > Antibody Collections > Immunity > CLEC10A Antibody - N-terminal region
CLEC10A Antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q8IUN9 |
| Other Accession | NP_878910 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 34kDa |
| Gene ID | 10462 |
|---|---|
| Alias Symbol | CLEC10A, CLECSF13, CLECSF14, HML, |
| Other Names | C-type lectin domain family 10 member A, C-type lectin superfamily member 14, Macrophage lectin 2, CD301, CLEC10A, CLECSF13, CLECSF14, HML |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 &mu, l of distilled water. Final Anti-CLEC10A antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | CLEC10A Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CLEC10A {ECO:0000303|PubMed:33724805} |
|---|---|
| Function | C-type lectin receptor involved in recognition of N- acetylgalactosamine (GalNAc)-terminated glycans by myeloid antigen presenting cells (APCs) (PubMed:15802303, PubMed:16998493, PubMed:17616966, PubMed:22213806, PubMed:33724805, PubMed:8598452). Binds in a Ca(2+)-dependent manner to alpha- and beta-linked GalNAc residues on glycoprotein and glycolipid antigens, including alphaGalNAc- and Galbeta1->3GalNAc-O-Ser/Thr also known as Tn and T antigens, LacdiNAc epitope GalNAcbeta1->4GlcNAc and its derivative GalNAcbeta1->4-(Fucalpha1->3)GlcNAc, O-linked core 5 and 6 glycans, and GM2 and GD2 gangliosides (PubMed:15802303, PubMed:23507963). Acts as a signaling receptor at the interface of APC-T cell interactions. On immature dendritic cells, recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and downregulates PTRPN/CD45 phosphatase activity with an impact on T cell activation threshold, cytokine production and proliferation. Modulates dendritic cell maturation toward a tolerogenic phenotype leading to generation of regulatory CD4- positive T cell subset with immune suppressive functions (PubMed:15802303, PubMed:16998493, PubMed:22213806). Acts as an endocytic pattern recognition receptor involved in antitumor immunity. During tumorigenesis, recognizes Tn antigens and its sialylated forms Neu5Ac-Tn and Neu5Gc-Tn expressed on tumor cell mucins. On immature dendritic cells, can internalize Tn-terminated immunogens and target them to endolysosomal compartment for MHC class I and II antigen presentation to CD8-positive and CD4-positive T cells, respectively (PubMed:15802303, PubMed:17616966, PubMed:17804752). |
| Cellular Location | Cell membrane; Single-pass type II membrane protein. Early endosome membrane; Single-pass type II membrane protein Lysosome membrane; Single-pass type II membrane protein. Note=Recycles between the plasma membrane and the endolysosomal compartment. Upon antigen binding, internalizes via endocytosis and then dissociates from antigen at acidic pH characteristic of endolysosomal vesicles |
| Tissue Location | Expressed in myeloid antigen presenting cells in lymph nodes and skin (at protein level). Expressed in dermal dendritic cells (at protein level). |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Suzuki N.,et al.J. Immunol. 156:128-135(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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$ 389.00
Cat# AI15484
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